Learn About CFRD
Common Signs and How It Develops
Cystic fibrosis-related diabetes (CFRD) occurs in over 30 percent of adults with CF. Women are diagnosed with CFRD more frequently than men.While CFRD has some features in common with type 1 diabetes (usually childhood onset) and type 2 diabetes (usually adult onset), it also has important differences that require a different management approach. So it’s good to know the specifics of CFRD.
Let’s start with the most common warning signs of diabetes in CF:
If you are having a hard time keeping your weight up, have lost weight without any explanation or have an unexplained decline in lung function, you should talk with your CF team to be screened for diabetes.
CFRD is caused by insulin insufficiency (not enough insulin). Insulin is a hormone that helps your body use food nutrients, allowing your cells to get all of the energy from the carbohydrates, protein and fat in the food you eat. Insulin is made in the pancreas in special cells called beta cells.
But CF can cause the cells in the pancreas to scar and not make insulin normally.
When there is not enough insulin available, people lose weight without trying (mostly muscle and fat stored in the body). This lack of insulin can also make lung function worse as high blood sugars can cause lungs to become more inflamed.
Be on the lookout for weight loss, since unexplained weight loss and a drop in lung function have been shown to occur 6 to 24 months before being diagnosed with CFRD.
Undiagnosed and untreated diabetes may shorten survival. Fortunately, treatment with insulin reverses muscle loss and helps with weight gain. It also improves survival.
The other symptoms (increased thirst, urinating more often, feeling tired) are caused by high blood sugar levels. It’s easy to miss these symptoms because people with CF often drink more (and then use the bathroom more) because of a dry mouth.
Learn more about CFRD by watching the Cystic Fibrosis-Related Diabetes webcast series.
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