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Study Name: Sildenafil in CF lung disease
Study Type: Interventional
Intervention Category: Anti-Inflammatory
Study Sponsor: Taylor-Cousar, Jennifer

Funding for this trial has been provided in full or in part by Cystic Fibrosis Foundation Therapeutics, Inc.
Study Phase: 2
Recruitment Status: Trial Completed
Study Drug(s): Sildenafil
Number of Participants Being Recruited: 20
Single / Multi-Center: Single Center
Chronic infection with Pseudomonas aeruginosa is a major cause of the lung damage seen in people with cystic fibrosis (CF). Sildenafil (Revatio®), a drug already used in other types of lung disease, may be helpful in decreasing symptoms related to lung inflammation and infection in people with CF. Study participants will receive sildenafil or placebo. Specimens of blood and sputum will be taken along with pulmonary function testing. The study will last 14 weeks.
Age: >= 12 Years
FEV1: >= 40 Percent Predicted
P. aeruginosa status: Not applicable
B. cepacia status: Negative
Other Primary Eligibility Requirements:

Note: Detailed eligibility criteria information may be available on If a specific trial listing for this trial is available, a link to the specific listing will be present in the "More Information" section below.
Sponsor Contact Information:
Trial Specific Link on
Clinical Research Terms Glossary: Click here
The sites listed below are currently recruiting subjects. Please note that this list generally lists either the pediatric or adult program but not both even though both programs may be recruiting subjects. Also, this list does not include sites that may be participating in the study but are not yet open for recruitment. If you are interested in this study please contact your center for more information.
  • National Jewish Health (Adult), Denver, CO, 80206
    Contact Information:
        Jones, Marion
        Phone: (303) 398-1265
  • University of New Mexico School of Medicine (Adult), Albuquerque, NM, 87131
    Contact Information:
        Redway, Abby
        Phone: (505) 272-5886
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