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Study Name: Effect of Pulmozyme® Withdrawal on Exercise Tolerance in People with Cystic Fibrosis
Study Type: Interventional
Intervention Category: Mucus Alteration
Study Sponsor: Genentech
Study Phase: 4
Recruitment Status: Trial Completed
Study Drug(s): Pulmozyme
Number of Participants Being Recruited: 100
Single / Multi-Center: Multi-Center
This study looks at the ability to do exercise, pulmonary function tests and other effects in people with CF when Pulmozyme® is withdrawn for 2 weeks. Pulmozyme® is an approved drug that thins mucus in the lungs of people with CF, making it easier to cough out the mucus. People whose CF symptoms are stable for 2 weeks prior to joining the trial will be able to participate. The study will last at most 35 days with four study visits. The exercise will be a 6-minute walk test on a flat surface. Outcome measures will also be pulmonary function; patient-reported health-related quality of life questions (HRQOL); and other measures.
Age: >= 14 Years
FEV1: Not Applicable
P. aeruginosa status: Not applicable
B. cepacia status: Not applicable
Other Primary Eligibility Requirements:

Note: Detailed eligibility criteria information may be available on If a specific trial listing for this trial is available, a link to the specific listing will be present in the "More Information" section below.
Sponsor Contact Information: Freemer, Michelle
Trial Specific Link on
Clinical Research Terms Glossary: Click here
The sites listed below are currently recruiting subjects. Please note that this list generally lists either the pediatric or adult program but not both even though both programs may be recruiting subjects. Also, this list does not include sites that may be participating in the study but are not yet open for recruitment. If you are interested in this study please contact your center for more information.
  • University of Alabama at Birmingham (Adult), Birmingham, AL, 35294
    Contact Information:
        Hathorne, Heather
        Phone: (205) 638-9568
  • Phoenix Children's Hospital (Adult), Phoenix, AZ, 85016
    Contact Information:
        Argel, Natalia
        Phone: (602) 933-0343
  • Children's Hospital of Los Angeles (Pediatric), Los Angeles, CA, 90027
    Contact Information:
        Vajda, Natalie
        Phone: (323) 361-3255
  • USC Keck School of Medicine (Adult), Los Angeles, CA, 90033
    Contact Information:
        Fukushima, Lynn
        Phone: (323) 442-5869
  • National Jewish Health (Adult), Denver, CO, 80206
    Contact Information:
        Jones, Marion
        Phone: (303) 398-1265
  • University of Miami (Adult), Miami, FL, 33136
    Contact Information:
        Mendes, Eliana
        Phone: (305) 243-2568
  • Emory University (Adult), Atlanta, GA, 30322
    Contact Information:
        Hunter, Eric
        Phone: (404) 785-3102
  • Georgia Regents University (Pediatric), Augusta, GA, 30912
    Contact Information:
        Stapp, Heidi
        Phone: (706) 721-7699
  • Rush University Medical Center (Pediatric), Chicago, IL, 60612
    Contact Information:
        Burke, Jenifer
        Phone: (312) 563-2273
  • Indiana University (Adult), Indianapolis, IN, 46202
    Contact Information:
        Bendy, Lisa
        Phone: (317) 948-7152
  • University of Kentucky (Adult), Lexington, KY, 40536
    Contact Information:
        Watts, Tammy
        Phone: (859) 257-5087
  • University of Michigan Health System (Adult), Ann Arbor, MI, 48109
    Contact Information:
        Kruse, Dawn
        Phone: (734) 615-3266
  • Wayne State University Harper University Hospital (Adult), Detroit, MI, 48201
    Contact Information:
        Driscoll, Debra
        Phone: (313) 745-2221
  • Spectrum Health Adult Cystic Fibrosis Care Center (Adult), Grand Rapids, MI, 49503
    Contact Information:
        Gile, Cynthia
        Phone: (616) 391-6148
  • The Minnesota Cystic Fibrosis Center (Adult), Minneapolis, MN, 55455
    Contact Information:
        Grover, Patricia
        Phone: (612) 626-7425
  • St. Louis Children's Hospital Washington University (Pediatric), St. Louis, MO, 63110
    Contact Information:
        Burks, Patricia
        Phone: (314) 454-5175
  • University of Mississippi Medical Center (Adult), Jackson, MS, 39216
    Contact Information:
        Adcock, Kim
        Phone: (601) 815-9172
  • Monmouth Medical Center (Pediatric), Long Branch, NJ, 07740
    Contact Information:
        Marra, Bridget
        Phone: (732) 222-4474
  • Morristown Medical Center (Adult), Morristown, NJ, 07962
    Contact Information:
        Martinez, Nancy
        Phone: (973) 971-5138
  • University of New Mexico School of Medicine (Adult), Albuquerque, NM, 87131
    Contact Information:
        Redway, Abby
        Phone: (505) 272-5886
  • Albany Medical College (Adult), Albany, NY, 12208
    Contact Information:
        Mokhiber, Katharine
        Phone: (518) 262-6608
  • Long Island Jewish Medical Center Adult Program (Adult), New Hyde Park, NY, 11040
    Contact Information:
        Wann, Li-Chen
        Phone: (516) 712-9608
  • SUNY Upstate Medical University (Adult), Syracuse, NY, 13210
    Contact Information:
        Lindner, Donna
        Phone: (315) 464-7525
  • University Hospitals Case Medical Center/Rainbow Babies and Children's Hospital (Pediatric), Cleveland, OH, 44106
    Contact Information:
        Ksenich, Roberta (Bobbi)
        Phone: (216) 844-5733
  • Toldeo Children's Hospital (Pediatric), Toledo, OH, 43606
    Contact Information:
        Houser, Kelly
        Phone: (419) 291-4630
  • University of Pittsburgh School of Medicine (Adult), Pittsburgh, PA, 15213
    Contact Information:
        Hartigan, Elizabeth
        Phone: (412) 692-7060
  • West Virginia University CF Center (Pediatric and Adult), Morgantown, WV, 26505
    Contact Information:
        Clark, Tammy
        Phone: (304) 293-5264
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