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Study Name: Early Treatment of New Onset of Methicillan Resistant Staphylococcus Aureus (MRSA) Growth in Respiratory Culture
Study Type: Interventional
Intervention Category: Anti-Infective
Study Sponsor: Muhlebach, Marianne

Funding for this trial has been provided in full or in part by Cystic Fibrosis Foundation Therapeutics, Inc.
Study Phase: 2
Recruitment Status: Trial Completed
Study Drug(s): Multiple systemic antibiotics
Number of Participants Being Recruited: 90
Single / Multi-Center: Multi-Center
Methicillan-resistant Staphylococcus aureus (MRSA) is one germ that can cause a lung infection in people with CF. MRSA is harder to treat than other forms of the germ Staphylococcus aureus. In both people with CF and people without CF, MRSA can make some people sick and other people can have the germ without getting sick. People with CF who grow MRSA in their respiratory culture for the first time will be randomly assigned to either an early eradication protocol group who will receive treatment because their culture is postive or to an observational group that will only receive treatment if respiratory symptoms occur (the current typical approach toward treatment of positive cultures for MRSA).
Age: 4 Years - 45 Years
FEV1: >= 30 Percent Predicted
P. aeruginosa status: Not applicable
B. cepacia status: Not applicable
Other Primary Eligibility Requirements:

Subjects must have first OR early MRSA colonization and MRSA at screening
Note: Detailed eligibility criteria information may be available on If a specific trial listing for this trial is available, a link to the specific listing will be present in the "More Information" section below.
Sponsor Contact Information: Hocevar-Trnka, Jasna
(206) 884-7527
Trial Specific Link on
Clinical Research Terms Glossary: Click here
The sites listed below are currently recruiting subjects. Please note that this list generally lists either the pediatric or adult program but not both even though both programs may be recruiting subjects. Also, this list does not include sites that may be participating in the study but are not yet open for recruitment. If you are interested in this study please contact your center for more information.
  • The Children's Hospital/University of Alabama at Birmingham (Pediatric), Birmingham, AL, 35233
    Contact Information:
        Hathorne, Heather
        Phone: (205) 638-9568
  • Children's Hospital Colorado (Pediatric), Aurora, CO, 80045
    Contact Information:
        Pardee, Churee
        Phone: (720) 777-6162
  • University of Florida (Pediatric), Gainesville, FL, 32610
    Contact Information:
        Baker, Dawn
        Phone: (352) 273-5417
  • University of Michigan Health System (Pediatric), Ann Arbor, MI, 48109
    Contact Information:
        Kruse, Dawn
        Phone: (734) 615-3266
  • Children's Hospitals and Clinics (Pediatric), Minneapolis, MN, 55404
    Contact Information:
        Johnson, Mahrya
        Phone: (612) 813-6384
  • St. Louis Children's Hospital Washington University (Pediatric), St. Louis, MO, 63110
    Contact Information:
        Burks, Patricia
        Phone: (314) 454-5175
  • University of North Carolina at Chapel Hill (Pediatric), Chapel Hill, NC, 27599
    Contact Information:
        Barlow, Carol
        Phone: (919) 966-9146
  • University of Nebraska Medical Center (Pediatric), Omaha, NE, 68198
    Contact Information:
        Acquazzino, Diane
        Phone: (402) 559-6275
  • University of Nebraska Medical Center (Pediatric), Omaha, NE, 68198
    Contact Information:
        Telfer, Raquel
        Phone: (402) 559-6275
  • Children's Medical Center of Dallas (Pediatric), Dallas, TX, 75235
    Contact Information:
        Hebert, Andrew
        Phone: (214) 456-5618
  • Cook Children's Medical Center (Pediatric), Fort Worth, TX, 76104
    Contact Information:
        Urbanek, Heather
        Phone: (682) 885-1244
  • Baylor College of Medicine (Pediatric), Houston, TX, 77030
    Contact Information:
        Schaap, Nicoline
        Phone: (832) 822-4252
  • Seattle Children's Hospital (Pediatric), Seattle, WA, 98105
    Contact Information:
        McNamara, Sharon
        Phone: (206) 987-3921 X1
  • University of Washington Medical Center (Adult), Seattle, WA, 98195
    Contact Information:
        Aitken, Moira
        Phone: (206) 543-3166
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