Effect of Sulforaphane in Broccoli Sprouts on Nrf2 activation
Funding for this trial has been provided in full or in part by Cystic Fibrosis Foundation Therapeutics, Inc.
Number of Participants Being Recruited:
Single / Multi-Center:
STUDY BACKGROUND INFORMATION:
Inflammation is an important factor in the pathophysiology of cystic fibrosis. The intracellular pathway, Nrf2, is important in the body's inflammatory response and has been shown to be deficient in CF cells. This trial looked at the whether consuming well chewed broccoli sprouts which releases sulforaphane activates the Nrf2 pathway. This was an 8 day trial where the study participant ate well - chewed broccoli sprouts. Specimens of blood, urine, and nasal epithelial samples will be taken during the trial.
18 Years - 49 Years
P. aeruginosa status:
B. cepacia status:
Other Primary Eligibility Requirements:
Note: Detailed eligibility criteria information may be available on clinicaltrials.gov. If a specific
trial listing for this trial is available, a link to the specific clinicaltrials.gov listing will be present in the "More Information" section below.
Ten healthy volunteers and 5 subjects with CF received 100 gms of broccoli sprouts daily for 5 days. Endpoints to determine whether sulforaphane in the broccoli sprouts would reduce white cells (PMNs) in both groups were measured. Mean change in log10 PMNs did not differ between the two groups. There were no other significant differences in other measures. A significantly higher baseline urine bromotyrosine was seen in subjects with CF compared to healthy volunteers.
No serious adverse events occurred during the study.
The summary of data provided here is from a poster presented at the Cystic Fibrosis Foundation North American CF Conference (2012). These data may be preliminary and have not been peer-reviewed.