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Study Name: Biomarkers and Exacerbations in CF
Study Type: Observational
Intervention Category: Not Applicable
Study Sponsor: Lechtzin, Noah

Funding for this trial has been provided in full or in part by Cystic Fibrosis Foundation Therapeutics, Inc.
Study Phase: Other
Recruitment Status: Recruiting
Study Drug(s): Not Applicable
Number of Participants Being Recruited: 60
Single / Multi-Center: Single Center
STUDY BACKGROUND INFORMATION:
Individuals with CF suffer from intermittent exacerbations of their disease, which is characterized by increased symptoms and drop in lung function. It is not clear that an individual who presents with mildly increased symptoms or a small drop in lung function should be treated with antibiotics nor how long antibiotics should be given when patients are treated for an exacerbation. This trial will measure biomarkers in blood, sputum, and exhaled breath at baseline and during the course of an exacerbation to to determine if biomarkers can be used to identify individuals who would benefit from initiation of antibiotic therapy as well as benefit from prolonged courses of antibiotics.
ELIGIBILITY
Age: >= 14 Years
FEV1: >= 25 Percent Predicted
P. aeruginosa status: Not applicable
B. cepacia status: Negative
Other Primary Eligibility Requirements:

Note: Detailed eligibility criteria information may be available on clinicaltrials.gov. If a specific trial listing for this trial is available, a link to the specific clinicaltrials.gov listing will be present in the "More Information" section below.
FOR MORE INFORMATION:
Sponsor Contact Information: Lechtzin, Noah
(410) 502-7047
nlechtz@jhmi.edu
Trial Specific Link on ClinicalTrials.gov: Not Available
Clinical Research Terms Glossary: Click here
PARTICIPATING SITES:
The sites listed below are currently recruiting subjects. Please note that this list generally lists either the pediatric or adult program but not both even though both programs may be recruiting subjects. Also, this list does not include sites that may be participating in the study but are not yet open for recruitment. If you are interested in this study please contact your center for more information.
MD
  • Johns Hopkins Adult CF Program (Adult), Baltimore, MD, 21205
    Contact Information:
        Callahan, Karen
        Phone: (443) 287-8983
        Email: kcallah1@jhmi.edu
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