Cystic Fibrosis Foundation - Click here for homepage
Stay Informed  |  Volunteer  |  Clinical Trials

In This Section

Quick Links

Find a Chapter

Get Assistance

Get Assistance - Cox Boys
We are here to help people with CF get the insurance coverage they need. Hear how the Foundation helped the Cox family.

Join us on Facebook!  Facebook 
Follow us on Twitter!  Twitter 
Follow us on Instagram!  Instagram 
Add us to your circle in Google+!

Google+ 

Subscribe to our channel on YouTube!  YouTube  


 

 

Print  

Cough Frequency May Serve as Measure in Evaluating CF Treatments

May 21, 2008

PTC Therapeutics today announced new data suggesting that the quantification of cough frequency may offer a clinically meaningful outcome measure in cystic fibrosis. Cough is one of the most prominent and burdensome disease-related symptoms in CF. According to data presented today at the 2008 International Conference of the American Thoracic Society, patients with CF cough a remarkable 324 to 1,569 times per day, with an average of 643 coughs per day. In comparison, healthy individuals generally cough fewer than 16 times in an entire day, according to the European Respiratory Journal (Hsu 1994).

“The ability to quantify cough represents a significant step forward in our understanding of one of the most prominent symptoms of CF,” said Preston W. Campbell, III, M.D., executive vice president for medical affairs of the Cystic Fibrosis Foundation.  “A significant reduction in cough frequency would be of real value to patients.”

The study was designed to assess cough frequency as a measure of clinical benefit.  Quantitative measurement was achieved using a new technology, the VivoMetrics® LifeShirt®, which integrates cough signals from chest wall motion transducers and a throat microphone and stores the data for computer analysis. FEV1 (Forced Expiratory Volume in the first second) and FVC (forced vital capacity)—key measures of lung function—were assessed by spirometry, and patients completed a symptom survey.


Read the full release.  

The Cystic Fibrosis Foundation is an accredited charity of the Better Business Bureau.