CFTR Antibodies & CFTR Modulators

On this page:

• CFTR Antibodies
• CFTR Modulators

CFTR Antibodies 

The Cystic Fibrosis Foundation Therapeutics (CFFT) Antibody Distribution Program was created to streamline researchers’ access to anti-CFTR antibodies for various aspects of CF drug discovery and development, as well as basic research.

The program is supported and administered by CFFT and capitalizes on the antibody expertise at Dr. John Riordan’s laboratory at the University of North Carolina at Chapel Hill (UNC-CH). 

The antibodies available through the program are not commercially available. (Note: additional anti-CFTR antibodies, as well as antibodies to certain proteins involved in cellular quality control, are available through the CFTR Folding Consortium.)

Overview of the Ordering Process

1. The first step in the process is to have a Material Transfer Agreement in place; the MTA is a contract between the supplying institution and the requesting institution guaranteeing responsible use of the supplied antibodies. The requestor’s institution must sign the MTA and send it to UNC-CH's contact, Tim Jensen. UNC-CH will return a copy of the MTA to the requestor after it has been approved and executed.
   
   
2. The requestor will fill out and forward the CFTR Antibody Distribution Program Order Form, including the shipping information, shipping account number and an associated purchase order number, or wire transfer, to cover the $40 shipping and handling fee for each antibody ordered.
   
   
3. The antibodies will be sent to the requestor directly from UNC-CH and the requesting institution will fulfill payment.

Please contact Tim Jensen at UNC-CH or reagents@cff.org with any questions, requests or orders.

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CFTR Modulators 

The Chemical Compound Distribution Program is sponsored by CFFT and administered by Professor Robert Bridges’ lab at Rosalind Franklin University of Science and Medicine (RFUSM).

The program’s main purpose is to enable CF research scientists to test known CFTR modulating compounds in different functional assays. In return, scientists are expected to share their experiences in working with the compounds for the general benefit of the community and in service of CFFT’s mission to find the means to cure and control cystic fibrosis.

Overview of the Ordering Process

1. The first step in the process is to have a Material Transfer Agreement in place; the MTA is a contract between the supplying institution and the requesting institution guaranteeing responsible use of the supplied modulators. The requestor’s institution must sign the MTA and send it to RFUSM’ contact Kim Hankin. RFUSM will return a copy of the MTA to the requestor after it has been approved and executed. 
   
   
2. The requestor will fill out and forward the CFTR Chemical Compound Distribution Program Order Form, including the shipping information and shipping account number.
   
   
3. The modulators will be sent to the requestor directly from RFUSM and the requesting institution will fulfill payment.

Please contact Kim Hankin or reagents@cff.org with any questions, requests or orders.

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Updated 06/18/12