TDN National Resource Centers 

Specialized procedures are often needed to measure the outcomes of CF clinical trials. These include both laboratory-based measurements, such as cytology and inflammatory markers, and interpretive outcomes, such as computed tomography and nasal potential difference.

The Therapeutics Development Network (TDN) National Resource Centers listed below provide expertise in the development, performance and evaluation of these measures.

Through standardization and careful attention to quality, the National Resource Centers help ensure CF clinical trials are safe and effective and yield high-quality data.

Continued research and development into new methodologies helps the TDN stay on the cutting edge as new types of therapies are developed.

Specialized Services 

National Resource Center personnel consult with study sponsors and investigators about use of specialized CF outcome measures and provide related support for specific studies.

Services offered may include, but are not limited to:

  • Assistance with selection of appropriate CF outcome measures 
  • Consultation on outcome measure implementation 
  • Training, qualification and ongoing support of study site operators
  • Performance of central testing, interpretation and/or data analysis

Contacting the National Resource Centers early in the study development process can help make study setup more efficient and ensure more timely and cost-effective completion of studies.

For more information about specific services, contact the center personnel listed below. Input on study development or implementation can also be arranged through the TDN Consulting Services Program.

Resource Center Directory 

  • Center for Biochemical Markers — The TDN Center for Biochemical Markers provides expertise in the measurement of biomarkers of inflammation and measures of nutritional status, such as vitamin and antioxidant levels, in a variety of biological specimens, including blood, sputum, bronchoalveolar lavage fluid and urine. Please see our test list and publications for more information.

University of Colorado School of Medicine, Aurora
Frank Accurso, MD, Laboratory Director 

back to top

  • Center for CF Microbiology — The TDN Center for CF Microbiology provides state-of-the-art support and expertise in the isolation, quantitation, identification and susceptibility testing of CF-specific pathogens for clinical trials.

Seattle Children’s Hospital
Jane L. Burns, MD, Laboratory Director 

back to top

  • Center for CFTR Detection — The TDN Center for CFTR Detection specializes in the performance and interpretation of nasal potential difference (NPD) traces and other measures of cystic fibrosis transmembrane conductance regulator (CFTR) detection in CF clinical trials, such as intestinal current measurements, lower airway potential difference measurements and sweat evaporimetry.

University of Alabama at Birmingham
Steven Rowe, MD, MSPH, Director 

back to top

  • Center for Diagnostic Imaging —  The TDN Center for Diagnostic Imaging facilitates and provides guidelines for the use of imaging procedures in CF clinical trials. These include, but are not limited to, computed tomography (CT), positron emission tomography (PET) magnetic resonance imaging (MRI), ultrasonography and chest radiography.

Baylor College of Medicine, Houston, Texas
R. Paul Guillerman, MD, Co-Director 
Specialties: Chest radiography and CT; abdominal imaging; PET imaging

University of Wisconsin at Madison
Scott K. Nagle, MD, PhD, Co-Director 
Specialty: Chest MRI

back to top

  • Center for Interpretive Cytology — The TDN Center for Interpretive Cytology provides expertise in the differential identification and interpretation of human cells from respiratory tract specimens.

Case Western Reserve University, Cleveland, Ohio
Jay Hilliard, BS, CCRP, Technical Director 

back to top

  • Center for Pediatric Lung Function — The TDN Center for Pediatric Lung Function provides expertise on performance of lung function testing on infants and preschool children for CF clinical trials. Measures used include infant and preschool lung function tests, forced oscillation, respiratory inductance plethysmography and multiple breath washout.

Indiana University School of Medicine, Indianapolis
Stephanie Davis, MD, Director 

Washington University, St. Louis, Missouri
Jessica Pittman, MD, MPH, Associate Director 

back to top

  • Center for Sweat Analysis — The TDN Center for Sweat Analysis offers expertise in the use of sweat electrolyte analysis as a specialized outcome measure of CFTR protein function in CF clinical studies. See our publications list for more information.

University of Colorado School of Medicine, Aurora
Frank Accurso, MD, Laboratory Director 

back to top 

Updated: 8/19/2014