Mucociliary Clearance Consortium

Understanding how alterations in the airway environment, including abnormal mucus and mucociliary transport, leads to the development of chronic airway diseases will yield more precise diagnoses, better standards of clinical care and advance new and effective treatments.

Focus

The mission of the Mucociliary Clearance Consortium is to:

Improve our understanding of how the airway environment (including airway surface liquid volume, ionic content, and glandular macromolecules) results in abnormal mucus and aberrant mucociliary transport
Determine the limits of CFTR, epithelial sodium channel, and other ion transporter activities required to maintain normal physiology
Examine whether mucin biogenesis and post-translational modification pathways are aberrant in CF, and determine their functional relationship to the ion transport environment
Develop new preclinical and clinical measures of mucociliary clearance to allow a better understanding of this process, prioritization of therapeutic compounds under development, and evaluation of downstream effects elicited by ion transport modulators

Consortium Membership

Sponsor	Institute
Steve Ballard, Ph.D. sballard@usouthal.edu	University of South Alabama
William Bennett, Ph.D. william_bennett@med.unc.edu	University of North Carolina at Chapel Hill
Brian Button, Ph.D. bbutton@med.unc.edu	University of North Carolina at Chapel Hill
C. William Davis, Ph.D. cwdavis@med.unc.edu	University of North Carolina at Chapel Hill
Scott Donaldson, M.D. scott_donaldson@med.unc.edu	University of North Carolina at Chapel Hill
Camile Ehre, Ph.D. cehre@med.unc.edu	University of North Carolina at Chapel Hill
Justin Hanes, Ph.D. hanes@jhu.edu	Johns Hopkins University School of Medicine
Mehmet Kesimer, Ph.D. kesimer@med.unc.edu	University of North Carolina at Chapel Hill
Paul Quinton, Ph.D. pquinton@ucsd.edu	University of California San Diego School of Medicine
Steve Rowe, M.D., MSPH smrowe@uab.edu	University of Alabama at Birmingham
Michael Rubinstein, Ph.D. mr@unc.edu	University of North Carolina at Chapel Hill
David Stoltz, M.D., Ph.D. david-stoltz@uiowa.edu	University of Iowa
Guillermo Tearney, M.D., Ph.D. tearney@partners.org	Massachusetts General Hospital
Dave Thornton, Ph.D. dave.thornton@manchester.ac.uk	University of Manchester
Jeff Wine, Ph.D. wine@stanford.edu	Stanford University

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Mucociliary Clearance Consortium

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Consortium Membership

Suggested Reading

Ion Transport, Mucus Secretion and Clearance

Mucus and Mucins

Novel Techniques and Protocols

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