Nesolicaftor (PTI-428)

Nesolicaftor is a type of modulator called an amplifier. Amplifiers increase the amount of CFTR protein in the cell. This makes more CFTR protein available for other therapies, such correctors and potentiators, to work on.

Status

Phase 2 studies were conducted to test the safety and effectiveness of nesolicaftor alone and in combination with two other CFTR modulators, posenacaftor (PTI-801) and dirocaftor (PTI-808). No further studies of these compounds are planned at this time.

Sponsor

This program was sponsored by Proteostasis Therapeutics. It was conducted through the Therapeutics Development Network.