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Clinical Trial Finder
Blaze a trail to better treatments and a cure for cystic fibrosis.
As a clinical trial volunteer, you are paving the way for new treatments. Search for trials that may be right for you using the filter on the left, or learn how to use the finder by watching this video.
Showing 97-108 of 212 studies
As a clinical trial volunteer, you are paving the way for new treatments. Search for trials that may be right for you using the filter on the left, or learn how to use the finder by watching this video.
Showing 97-108 of 212 studies
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Restore CFTR ProteinCompleted with Results
SNO4: Study of N91115 in people with cystic fibrosis ages 18 and older with two copies of F508del-CFTR mutation , protocol number Nivalis N91115-2CF-03This study looked at the safety and tolerability of the drug, N91115, in people with CF that had two copies of the F508del mutation. Researchers also looked at the effect of N91115 on CFTR biomarkers, such as sweat chloride value. Biomarkers help researchers understand how active or inactive a disease is.
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Age:
18 Years and Older
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Mutation(s):
Two Copies F508del
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FEV1% Predicted:
40% or greater
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Number of Visits:
8
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Length of Participation:
6 weeks
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Restore CFTR ProteinCompleted with Results
Phase 3 study of VX-661 and ivacaftor in people with cystic fibrosis , protocol number Vertex VX-661-106This study evaluated the safety and effectiveness of the drug VX-661 in combination with ivacaftor (Kalydeco®) compared with placebo. This study was for people with CF who have two copies of the F508del CFTR mutation.
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Age:
12 Years and Older
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Mutation(s):
Two Copies F508del
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FEV1% Predicted:
40 to 90%
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Number of Visits:
11
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Length of Participation:
32 weeks
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Restore CFTR ProteinCompleted with Results
Phase 2 study of riociguat in adults with CF , protocol number Bayer BAY 63-2521/ 17020This study evaluated the safety, tolerability, and effectiveness of the oral drug riociguat in adults with CF who have two copies of the F508del mutation and were not receiving CFTR modulator therapy.
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Age:
18 Years and Older
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Mutation(s):
Two Copies F508del
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FEV1% Predicted:
60 to 90%
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Number of Visits:
9
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Length of Participation:
28 days
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Restore CFTR ProteinCompleted with Results
Phase 3 study of Ataluren in people with CF who have a nonsense mutation and are not taking aminoglycosides , protocol number PTC124-GD-021-CFThis study evaluated the safety and effectiveness of the drug Ataluren (PTC124®) compared with placebo. This study was for people with CF who have a nonsense mutation and were not receiving chronic inhaled aminoglycosides.
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Age:
6 Years and Older
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Mutation(s):
One Copy F508del or No Copies F508del
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FEV1% Predicted:
60 to 90%
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Number of Visits:
10
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Length of Participation:
56 weeks
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Restore CFTR ProteinCompleted with Results
Study of VX-661 combined with ivacaftor in adults with cystic fibrosis , protocol number Vertex VX-661-103This study evaluated the safety and the best way to dose VX-661 in combination with ivacaftor. This study was for adults with CF who have two copies of the F508del CFTR mutation.
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Age:
18 Years and Older
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Mutation(s):
Two Copies F508del
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FEV1% Predicted:
40 to 90%
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Number of Visits:
8
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Length of Participation:
20 weeks
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Restore CFTR ProteinCompleted with Results
Vertex 809/770 in People with Cystic Fibrosis and F508del-CFTR mutation , protocol number Vertex VX-809-102This study looked at the safety and effectiveness of VX 809 (lumacaftor) when taken alone and when in combination with VX770 (ivacaftor) when given to people with CF who have either one or two copies of the F508del-CFTR mutation.
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Age:
18 Years and Older
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Mutation(s):
Two Copies F508del or One Copy F508del
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FEV1% Predicted:
40% or greater
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Number of Visits:
6
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Length of Participation:
2 months
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Restore CFTR ProteinCompleted with Results
Vertex Lumacaftor (VX-809) and Ivacaftor in People with CF aged 12 years and older and have two copies of the delF508 CFTR mutation (TRANSPORT) , protocol number Vertex VX-809-104This was the second of two nearly identical Phase 3 trials looking at the safety and effectiveness of the study drug VX 809 (lumacaftor) in combination with ivacaftor (Kalydeco) in people with CF who are aged 12 years and older and have two copies of the F508del-CFTR mutation.
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Age:
12 Years and Older
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Mutation(s):
Two Copies F508del
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FEV1% Predicted:
40% or greater
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Number of Visits:
11
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Length of Participation:
28 weeks
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Restore CFTR ProteinCompleted with Results
Vertex Lumacaftor (VX-809) and ivacaftor in people with CF who are aged 12 years and have two copies of the delF508 CFTR mutation (TRAFFIC) , protocol number Vertex VX-809-103This was the first of two nearly identical Phase 3 trials looking at the safety and effectiveness of the study drug VX 809 (lumacaftor) in combination with ivacaftor in people with CF who are aged 12 years and older and have two copies of the F508del-CFTR mutation.
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Age:
12 Years and Older
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Mutation(s):
Two Copies F508del
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FEV1% Predicted:
40% or greater
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Number of Visits:
10
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Length of Participation:
24 weeks
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Restore CFTR ProteinCompleted with Results
SNO1: Study of N6022 in people with CF , protocol number Nivalis N30 N6022-1CF1-04This study tested the safety, tolerability of N6022 and its effects on CFTR biomarkers in people with CF.
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Age:
18 Years and Older
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Mutation(s):
Two Copies F508del
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FEV1% Predicted:
40% or greater
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Number of Visits:
10
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Length of Participation:
6 weeks
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Restore CFTR ProteinCompleted with Results
Ivacaftor in People with CF age 2 to 5 years with a CFTR Gating Mutation , protocol number Vertex VX-770-108This was an open-label study designed to look at the safety and effectiveness of ivacaftor (Kalydeco®) in children with CF who had at least one copy of a CFTR gating mutation.
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Age:
2 Years to 5 Years
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Mutation(s):
One Copy F508del or No Copies F508del
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FEV1% Predicted:
No FEV1 Limit
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Number of Visits:
11
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Length of Participation:
32 weeks
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Restore CFTR ProteinCompleted with Results
Ivacaftor in People with CF who have a Non G551D Gating Mutation (KONNECTION) , protocol number Vertex VX-770-111The purpose of this trial was to look at the safety and effectiveness of ivacaftor (Kalydeco) in people with cystic fibrosis (CF) who have a non-G551D cystic fibrosis transmembrane regulator (CFTR) gating mutation (any one of the following CFTR mutations: G178R, G551S, S549N, S549R, G970R, G1244E, S1251N, S1255P, or G1349D).
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Age:
6 Years and Older
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Mutation(s):
One Copy F508del or No Copies F508del
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FEV1% Predicted:
40 to 105%
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Number of Visits:
11
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Length of Participation:
40 weeks
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Restore CFTR ProteinCompleted with Results
Ivacaftor in People with CF who have the R117H-CFTR mutation (KONDUCT) , protocol number Vertex VX-770-110This study looked at the safety and effectiveness of ivacaftor (Kalydeco) in people with CF who have the R117H-CFTR mutation.
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Age:
6 Years and Older
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Mutation(s):
One Copy F508del or No Copies F508del
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FEV1% Predicted:
40 to 105%
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Number of Visits:
8
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Length of Participation:
28 weeks
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Studies in this tool are multi-center studies facilitated by the Cystic Fibrosis Therapeutics Development Network. For a complete list of cystic fibrosis related studies, visit www.clinicaltrials.gov.
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