Drug Development Pipeline
IONIS-ENaC-2.5Rx is a compound designed to block the function of the sodium (Na+) channel found in the lungs. These channels move sodium and water away from the airway surface. Blocking these channels may help maintain fluid within the airways to improve mucus clearance.
A phase 1/2a study to test the safety and tolerability of IONIS-ENaC-2.5Rx in healthy volunteers and in adults with CF was completed. No further development in CF is planned at this time.
This program was sponsored by Ionis Pharmaceuticals and partially funded by the Cystic Fibrosis Foundation.
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