Drug Development Pipeline
IONIS-ENaC-2.5Rx is a compound designed to block the function of the sodium (Na+) channel found in the lungs. These channels move sodium and water away from the airway surface. Blocking these channels may help maintain fluid within the airways to improve mucus clearance.
A phase 1/2a study to test the safety and tolerability of IONIS-ENaC-2.5Rx in healthy volunteers and in adults with CF is underway.
This program is sponsored by Ionis Pharmaceuticals and partially funded by the Cystic Fibrosis Foundation.
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