Drug Development Pipeline
VX-445 + tezacaftor + ivacaftor
Restore CFTR Function
This program is testing VX-445 in combination with tezacaftor and ivacaftor. VX-445 and tezacaftor (VX-661) are new CFTR correctors. Correctors are drugs designed to fix the defective CFTR protein so that it can move to the proper place on the cell surface. Once CFTR protein reaches the cell surface, ivacaftor helps facilitate the opening of the chloride channel to allow chloride and sodium (salt) to move in and out of the cell.
A phase 1 and 2 study to test the safety and tolerability of VX-445 has been completed, and two phase 3 studies to test the safety and effectiveness of VX-445 in people with CF 12 years and older are ongoing.
This program is sponsored by Vertex Pharmaceuticals and partially funded by the Cystic Fibrosis Foundation. This program is being conducted within the Therapeutics Development Network (TDN).
Recent VX-445 + tezacaftor + ivacaftor Studies
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