Research We Fund

The Cystic Fibrosis Foundation is the world's leader in the fight against CF, and our scientific portfolio reflects our drive to provide effective treatments and — one day — a cure to every individual with this disease.

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We continue to make tremendous progress towards these goals. Last year the U.S. Food and Drug Administration (FDA) expanded the approval of three CFTR modulators, including Trikafta®, using in vitro data to people with certain mutations. It also expanded Kalydeco® to infants as young as four months. However, we will not rest until everyone has a therapy that addresses the underlying cause of their disease.

With this commitment in mind, the Foundation launched our Path to a Cure, an ambitious research initiative to accelerate treatments for everyone with CF and ultimately deliver a cure. We intend to allocate a half billion dollars to the effort through 2025 and have already seen an 180% increase in funding for this area of research from 2018.

It is also critical to continue to develop new and improved treatments for complications from the disease. We are building on the current momentum, funding an innovative research portfolio and collaborating with top scientists from around the world to deliver the next generation of transformative breakthroughs in CF. To ensure the advancement of potential therapies, we provide research funding and expertise to draw the best scientific minds and technologies into CF. Last year we held more than 230 meetings with over 120 companies — 61 of which were new to CF — and are currently funding nearly 50 different industry programs.

Despite the many challenges posed by the pandemic, in 2020 the CF Foundation funded approximately $248 million in laboratory research, preclinical drug development, clinical and real-world research, and high-quality, specialized care and training — more than at any other time in the history of the Foundation and nearly a third more than just the previous year.

This image shows the Medical Program Growth from 2013 to 2020. In 2013, we invested $104 million. In 2020, we invested $248 million in care, clinical/real world research, drug discovery/development, and basic science.
Medical Program Growth for 2013 to 2020

Our Investment in Research

The CF Foundation spent a total of $218.1 million on research and development as well as the CF Foundation Therapeutics Lab in 2020. 

Our Investment in Research


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