Clinical Pilot and Feasibility Award

The Clinical Pilot and Feasibility Award is intended to support a project involving human subjects or samples that will develop and test new hypotheses and/or new methods in research areas relevant to cystic fibrosis.

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The intent of the Clinical Pilot and Feasibility Award is to enable investigators to collect sufficient preliminary data to determine the best strategies and methods for approaching a major question that ultimately will require assessment through a larger scale research and/or multi-center, collaborative clinical trial.

Support may be requested for $80,000 annually (plus 12 percent for indirect costs) for up to two years.

Applicants must be independent investigators. Fellows may submit applications; however, funding will be considered only if they will hold a faculty-level appointment at the time of the award. Industry-sponsored research projects are not eligible for this award.

Special consideration will be given to those projects that pursue new approaches, study under-researched topics, or investigate more creative avenues of research to address the problems of cystic fibrosis. Applications for continued funding of existing projects, or for long-term support of an investigator, will not be considered.

Areas of Encouragement

In addition to CF Foundation Areas of Interest, extensive survey input from the CF community (people with CF, family members, and caregivers) have identified key research Areas of Encouragement that are most important to them. The areas selected by the CF community are listed below in order of prioritization. Applications may address any topic area advancing CF care, treatment, or research. However, applications addressing the following areas in CF are particularly encouraged:

  1. Respiratory microorganism detection and treatment
  2. Gastrointestinal symptoms (including, but not limited to, gastroesophageal reflux disease (GERD), Distal Intestinal Obstruction Syndrome  (DIOS), and pancreatitis)
  3. Reducing treatment burden
  4. CF-related diabetes
  5. Diet and nutrition
  6. Mental health
  7. CF-related liver disease
  8. Exercise
  9. Sinus disease
  10. Allergies and asthma in CF
  11. Alternative/holistic treatments and therapies
  12. Sexual reproductive health
  13. Bone/joint health
  14. Pain management

More information regarding the research priorities of the CF Foundation can be found here. For specific questions regarding your proposal and the CF Foundation's research priorities, please contact the Program Officer, Dara Riva (

Policies and Guidelines

Please review the Spring 2022 Policies and Guidelines for complete submission information.


All letters of intent and full applications for Spring 2022 must be submitted online at by 5 p.m. ET.

Spring 2022

  • Letter of Intent: August 16, 2021
  • Full application: January 25, 2022

For More Information

Those who are interested in any funding programs offered by the Cystic Fibrosis Foundation may get further information, or discuss the potential relevance of their studies or research by contacting the Grants and Contracts Office at

Please Direct Inquiries to:

Grants and Contracts Office
Cystic Fibrosis Foundation
4550 Montgomery Ave.
Suite 1100 N
Bethesda, MD 20814

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Clinical Pilot and Feasibility Award Policies and Guidelines Download (PDF)
Role of Community Members in CF Clinical Research Download (PDF)
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