Clinical Trial Finder
Blaze a trail to better treatments and a cure for cystic fibrosis.
Due to COVID-19, restrictions regarding enrollment may be in place. Please contact study sites directly to learn about their screening and enrollment status.
As a clinical trial volunteer, you are paving the way for new treatments. Search or filter for trials that may be right for you, or learn more about what it means to be a trailblazer.
Showing 1-6 of 184 studies
As a clinical trial volunteer, you are paving the way for new treatments. Search for trials that may be right for you using the filter on the left, or learn more about what it means to be a trailblazer.
Showing 1-6 of 184 studies
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Restore CFTR FunctionEnrolling
Study of the triple-combination modulator, elexacaftor/tezacaftor/ivacaftor, in children 2-5 years old with cystic fibrosis (Part A) , protocol number Vertex VX20-445-111 Part AThis study will look at the safety and effectiveness of the triple-combination therapy, elexacaftor/tezacaftor/ivacaftor (Trikafta®), in children ages 2-5 years old with CF. These drugs are intended to help CFTR protein function closer to normal.
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Age:
2 Years to 5 Years
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Mutation(s):
Two Copies F508del or One Copy F508del
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FEV1% Predicted:
No FEV1 Limit
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Number of Visits:
5
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Length of Participation:
53 days
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Anti-InflammatoryEnrolling
Study to evaluate CB-280 in adults with cystic fibrosis and chronic Pseudomonas aeruginosa , protocol number Calithera CX-280-202This study will look at the safety and tolerability of CB-280, an oral drug taken twice a day intended to treat infections in the lung and reduce inflammation. Multiple doses of the drug will be tested in adults with cystic fibrosis and chronic Pseudomonas aeruginosa to find the best dose.
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Age:
18 Years and Older
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Mutation(s):
No Mutation Requirement
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FEV1% Predicted:
40 to 90%
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Number of Visits:
6
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Length of Participation:
2 months
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Anti-InfectiveEnrolling
Study to evaluate inhaled AP-PA02 in adults with cystic fibrosis and chronic Pseudomonas aeruginosa (Armata Phase 1b/2 MAD) , protocol number Armata AP-PA02-101This study will look at the safety and tolerability of inhaled AP-PA02, a bacteriophage drug intended to treat infections in the lung. Bacteriophages are specialized viruses that kill very specific bacterial strains. Multiple doses of the drug will be tested in adults with cystic fibrosis and chronic Pseudomonas aeruginosa to find the best dose.
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Age:
18 Years and Older
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Mutation(s):
No Mutation Requirement
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FEV1% Predicted:
60% or greater
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Number of Visits:
10
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Length of Participation:
31 days
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Nutritional-GIEnrolling
OPTION 2: Study of AzurRX MS1819 in enteric capsules in adults with cystic fibrosis and exocrine pancreatic insufficiency , protocol number AzurRX AZ-CF2002This study will look at the safety and effectiveness of the drug MS1819 in enteric capsules as a pancreatic enzyme replacement therapy (PERT).
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Age:
18 Years and Older
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Mutation(s):
No Mutation Requirement
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FEV1% Predicted:
30% or greater
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Number of Visits:
10
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Length of Participation:
8 weeks
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ObservationalEnrolling
Rare mutation cell collection (RARE) , protocol number RARE-OB-16This study is taking place at six regional care centers across the U.S. Researchers will collect and make available for study cells from people with rare CFTR mutations.
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Age:
12 Years and Older
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Mutation(s):
One Copy F508del or No Copies F508del
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FEV1% Predicted:
No FEV1 Limit
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Number of Visits:
1
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Length of Participation:
2 days
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OtherEnrolling
Study of SPI-1005 in people with CF ages 18 and older , protocol number Sound Pharma SPI-3005-501.2This study will test the safety and tolerability of SPI-1005, a drug intended to prevent and treat hearing loss caused by aminoglycosides.
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Age:
18 Years and Older
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Mutation(s):
No Mutation Requirement
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FEV1% Predicted:
40% or greater
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Number of Visits:
6
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Length of Participation:
49 days
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Showing 1-6 of 184 studies
Studies in this tool are multi-center studies facilitated by the Cystic Fibrosis Therapeutics Development Network. For a complete list of cystic fibrosis related studies, visit www.clinicaltrials.gov.
Related Topics
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Questions to Ask When Considering a Specific Trial
Clinical trials that test potential drugs and therapies in people with cystic fibrosis are a major part of CF research. They take place at Cystic Fibrosis Foundation-accredited care centers all over the United States and enroll people with CF of all ages.
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Patient Safety Is a Priority
Nothing is more important than patient safety in developing new treatments for cystic fibrosis. The U.S. government requires that all clinical trials are supervised for safety, and the Cystic Fibrosis Foundation adds additional measures to protect study volunteers.
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Trikafta™
The following is a collection of information and news about Trikafta™, the triple-combination modulator therapy that was approved by the U.S. Food and Drug Administration on Oct. 21, 2019.
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