Cystic Fibrosis-Related Diabetes

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Cystic fibrosis-related diabetes (CFRD) is a unique type of diabetes that is common in people with CF. With early diagnosis and proper treatment, CFRD can be managed successfully.

Causes of CFRD

There are two types of diabetes in people without cystic fibrosis. Type 1 diabetes is an autoimmune disease that occurs when the body's immune system attacks and destroys the cells in the pancreas that make insulin (beta cells). Insulin helps the body absorb and use the energy from food. This helps maintain good nutrition and lung function in people with CF.

Type 1 diabetes is most commonly diagnosed in childhood. People with type 1 diabetes need to take insulin to stay alive. Type 2 diabetes occurs more often in adults who are overweight or obese, and is caused by the lack of a normal response to insulin in addition to the pancreas not making enough insulin.

CFRD shares some features with both type 1 and type 2 diabetes. In people with CF, the thick, sticky mucus that is characteristic of the disease causes scarring of the pancreas. This scarring prevents the pancreas from producing normal amounts of insulin, so, like people with type 1 diabetes, they become insulin deficient. Their pancreas still makes some insulin, but not enough to stay healthy and maintain good nutrition.

Additionally, people with CFRD may not respond to insulin in the right way like people with type 2 diabetes, especially when sick, when taking steroid medication, and when pregnant. This is referred to as being "insulin resistant."

Symptoms, Screening, and Diagnosis

People with CFRD may not experience any symptoms. Some diabetes symptoms are similar to other CF symptoms you may already have. Many people with CFRD do not know they have CFRD until they are tested for diabetes.

Some common symptoms, like increased thirst and urination, are caused by high blood sugar levels, known as hyperglycemia. Other symptoms of CFRD are excessive fatigue, weight loss, and unexplained decline in lung function.

The CF care guidelines for CFRD recommend that people with CF ages 10 and older be tested every year for CFRD with an oral glucose tolerance test (OGTT). The OGTT is the best way to diagnose CFRD and is usually done in the morning after an eight-hour fast. If you are diagnosed with CFRD, you will receive proper treatment in order to feel better, gain weight, and improve your lung function.

Listen to Andrea Kelly, M.D., talk about CFRD and what's changed since she's been in the field of CF.

Watch this webcast to learn more about CFRD diagnosis and screening.

Treating CFRD

The goal for treating CFRD is to keep blood sugar (glucose) at normal or near-normal levels. Doing so will help you gain weight, maintain muscle mass, feel better, and have more energy. Maintaining normal glucose levels also lowers the risk of problems caused by diabetes.

CFRD can be well managed with insulin, along with monitoring your blood sugar levels, eating your usual high-calorie diet, and staying active.

There are many types of insulin, which are grouped by how fast they work and how long they last in the body. Insulin is injected into the body and helps your body cells absorb the energy (calories) from the food you eat. Calories in food come from carbohydrates, protein, and fat. Insulin helps the body cells absorb these three nutrients so you can achieve and maintain a healthy body weight and good nutritional status.

People with CFRD still need to eat the same high-calorie, high-protein, high-fat, high-salt diet to help achieve and maintain a healthy body weight. Since foods with carbohydrates turn into blood glucose when eaten, people with CFRD need to count the carbohydrates in the foods they eat so they can give themselves the right amount of insulin. Your diabetes care team will help you determine the amount of insulin you need for your carbohydrates.

Physical activity like exercise is good for lung function and can also improve your body's response to insulin. People with CFRD are encouraged to do at least 150 minutes of some type of moderate aerobic exercise -- activities that require you to breathe in oxygen, like jogging or playing sports -- every week. Monitoring your blood sugar levels will allow you to remain active since exercise may cause the levels to drop when muscles use the sugar for energy.

If you are diagnosed with CFRD, your CF care team may expand to include an endocrinologist (a doctor with special training in the treatment of diabetes) and certified diabetes educators. Working with you, this team will design a treatment plan to help you manage your diabetes while also maintaining your health with CF.

Download the manual, "Managing Cystic Fibrosis-Related Diabetes, An Instruction Guide for Patients and Families."

The manual is also available in Spanish: "El Manejo de la Diabetes Relacionada con la Fibrosis Quística."